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Here too there are several mechanisms in effect simultaneously: B12 is a strong antioxidant that has proven almost as potent as superoxide dismutase (oxidative stress) (68) B12 is a scavenger of nitrogen radicals and also controls their production (nitrosative stress) (69, 70) B12 plays a role in the creation of glutathione , a central antioxidant (71) Through all of these mechanisms, vitamin B12 plays an important regulating role in all inflammatory diseases and in this way, protects the health of the nerves

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This suggested that Gdh1p possibly affects the levels of -ketoglutarate at the SIR-regulated telomeric loci

Answer: You may notice changes in as little as710 days with consistent use