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In the presence of cellular nutrients, RagA or B are loaded with GTP, while RagC or D are loaded with GDP (Valvezan and Manning, 2019)

10.1002/hep.1840360607 Hepatology 181 TorrentsD.EstvezR.PinedaM.FernndezE.LloberasJ.ShiY

This again is a major oversimplification, as the theory (and the use of HRV as a general proxy) assumes namely that consistent patterns in the activity of different vegetative efferents (towards the heart, lung, gut etc) should be observed, but this prediction is frequently not verified (319)