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We continue to believe the more tolerable safety profile of Aucatzyl will make it the preferred treatment option for patients with adult ALL and support majority market share over time, William Blair analyst Matt Phipps said in a Friday note

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In essence, each component supports different steps of metabolic pathways, for example, energy generation from carbohydrates and fats requires B, B, B, and B in sequence

The main rationale for cycling rather than continuous use involves conservative safety practices given limited long-term human data, cost management, and theoretical concerns about receptor desensitization with extended exposure