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Additionally, localized and systemic immunosuppression is also induced

Proc Natl Acad Sci USA 101:59645969

10.1016/j.amolm.2025.100075 107 OkudaT.KokubuE.KawanaT.SaitoA.OkudaK.IshiharaK

Hypermethylation of the transporter 1 ATP-binding cassette subfamily B member (TAP1) has been shown to suppress TAP1 expression in immunoreactive cancer stem cells (CSCs) within murine models of breast carcinoma, these CSCs manifest a downregulation in the expression of transporter associated with antigen processing genes and co-stimulatory molecules, thereby reducing their sensitivity to T-cell-mediated immune surveillance and potentially culminating in immunotherapy resistance