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(as long as the causative factor for B 12 deficiency persists, therapy should be continued) Evidence from animal and human studies shows that B 12 also has neuroprotective and anti-inflammatory properties, 15 and intervention studies in humans have reported beneficial effects of better B 12 status or B 12 therapy in multiple sclerosis, 16 Parkinsons disease, 17 myalgic encephalomyelitis, 18 autism, 19 and (administering very high doses of methylcobalamin) in amyotrophic lateral sclerosis

The two-year study found that the supplementation improved B-vitamin status, decreased homocysteine concentrations, and reduced risk of total fractures compared to placebo (117)

Small amounts of the vitamin are also available in eggs, cheese, yogurt, and fortified cereal products

[26] DNA methylation is involved in the functioning of genes and is an essential epigenetic control mechanism in mammals