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In addition, they found that both the transcript and the protein levels of Nrf2 and the detoxifying/antioxidant enzymes HO1 and NQO1 were significantly decreased [252]

By utilizing H 2 O 2 we mimic the highly oxidative environment of intestinal inflammation and further our understanding of the macrophages response to this environment

Franklin A, Stella N

Figure 3 5.1 Epigenetic regulatory mechanisms EED exposure fundamentally alters the epigenetic landscape through modifications to DNA methylation patterns, histone modifications, and non-coding RNA expression profiles, creating molecular changes that persist across generations and potentially affect offspring health in unprecedented ways