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Metabolic reprogramming is a prominent hallmark of tumors, with tumor cells autonomously modulating adaptations through diverse metabolic pathways to meet heightened bioenergetic and biosynthetic demands, which are crucial for proliferation and survival while alleviating oxidative stress

On balance, the future pipeline targeting cancer metabolism, with specific regard to inhibiting PHGDH, looks hopeful in ameliorating cancer metastasis and disease progression

Mutant p53 proteins bind DNA in a DNA structure-selective mode

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