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A mild deficiency may have no symptoms, but a more severe or prolonged deficiency can exhibit the following: Microcytic anemia Skin conditions Depression Confusion Lowered immunity Certain conditions can increase the risk of developing a deficiency by interfering with the absorption of vitamin B6: Kidney disease Autoimmune intestinal disorders like celiac disease, ulcerative colitis, and Crohns disease Autoimmune inflammatory disorders such as rheumatoid arthritis Alcoholism Toxicity It is quite unlikely to reach a toxic level of vitamin B6 from food sources alone

doi: 10.3389/fonc.2023.1116438 115 ChoudharyGSPellagattiAAgianianBSmithMABhagatTDGordon-MitchellSet al

In this framework, ferroptosis has surfaced as a crucial mechanism underlying endothelial damage, cardiomyocyte mortality during ischemiareperfusion events, and the susceptibility of atherosclerotic plaques (5, 6)

Thus, immune responses to life saving therapeutics such as Enzyme Replacement Therapies (ERT) for Lysosomal Storage Diseases and Factor VIII for Hemophilia A constitute a severe risk necessitating mitigating strategies