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Depression correlates with increased plasma levels of inflammatory cytokines and a dysregulated oxidant/antioxidant balance in HIV-1-infected subjects undergoing antiretroviral therapy

ALA, traditionally recognized for its antioxidant properties, indirectly attenuates ferroptotic signaling by enhancing glutathione concentrations and Nrf2 activity, which serves to inhibit iron-catalyzed lipid radical formation (92)

These results track with existing in vivo, in vitro, and in silico evidence supporting GSHs role in maintaining redox homeostasis during diving in marine mammals [18, 20,21,22, 25, 26, 63]