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TMAO is produced in the liver from trimethylamine (TMA), which is itself produced by gut bacteria when they process L-carnitine, choline and lecithin, compounds found meat, eggs and dairy products (with L-carnitine being particularly abundant in red meat)

Both BuShenHuaZhuo formula and YulinTongBu formula can reduce the levels of lipopolysaccharide (LPS) and inflammatory cytokines such as TNF-, IL-6 and IL-8 in the serum of PCOS rats, and inhibit the inflammatory response mediated by the nuclear factor-B (NF-B) signaling pathway (79), but also enhance the expression of tight junction proteins (occludin and claudin1) and inhibit the expression of key genes and proteins in the TLR4/NF-B signaling pathway (85)

Promotes energy for weight loss by utilizing fat

For example, the pro-autophagy protein, p62, is also a downstream target the of survival and inflammatory pathway, NF-kB (115, 116)