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The compound significantly reduced lesion area in ethanol-induced and stress-induced models compared to controls, establishing the gastroprotective profile that would drive subsequent research (Sikiric et al., 1993, Journal of Physiology Paris

In the same way, substituting a hydroxyl group for the fifth carbon of the A ring in irisolone ( 7 ) decreased its antioxidant capacity in comparison to irilone ( 4 )

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The result can be higher effective exposure metrics, shorter delay before systemic appearance, and lower variability among repeated doses