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Keywords: celiac disease, gliadin peptides, nutrigenetic, nutrigenomic, proteomic, fitonutrients, oxidative stress, inflammation Abbreviations AA arachidonic acid COX-2 cycloxygenase-2 cPLA2 cytosolic phospholipase A2 CD celiac disease DHA docosahexaenoic acid EPA eicosapentaenoic acid GDF gluten free diet EGFR epidermal growth factor receptor HLA human leukocytes antigen IFN- interferon-gamma GSSG oxidised glutathione GSH reduced glutathione NO nitric oxide iNOS inducible-nitric oxide synthase PUFAs polyunsaturated fatty acids ROS reactive oxygen species RNS reactive nitrogen species TJ tight junctions tTG tissue transglutaminase 1