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On chr7q21, the most significant SNP ( P = 2.3 10 9 ) was rs2714700, a SNP between the MAGI2 and GNAI1 genes (Supplementary Fig

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When multiple mental, emotional or behavioral signs like the following are seen over an extended period, a person has passed over into addiction: The person wishes to reduce their use but they are unsuccessful They crave the drug They neglect social obligations Poor performance at work or in school They are experiencing problems among family and friends They skip the social, occupational or preferred activities so they can use marijuana They experience consequences related to its use but are unwilling or unable to stop They need higher doses to get the effects they are seeking The signs that a person has crossed the line into addiction are often accompanied by these signs that may also accompany heavy use: Depression Anxiety Paranoia Memory problems Difficulty controlling emotions Sudden mood changes Feeling that life is unreal Secretive behavior Using the drug in situations that may be dangerous (like driving) Reduced motivation Poor performance at school or work Physical Signs of Marijuana Addiction The following physical signs may be seen if a person is addicted or a long-term, heavy user: Chronic cough or wheeze Weight gain Sleep disturbances Lung or heart damage Poor coordination and motor skills Fatigue and lethargy Marijuana: What You Need to Know Every year, marijuana becomes more pervasive in the world