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doi: 10.1038/cddis.2015.49 45 HaraT.NakamuraK.MatsuiM.YamamotoA.NakaharaY.Suzuki-MigishimaR.et al

However, the relatively insufficient recognition of neural regulation and intracellular microbes has hampered the thorough understanding of their roles in lung-specific metastasis

This includes the regulation of hepatic cholesterol synthesis and the promotion of cholesterol excretion and metabolism, ultimately leading to reduced blood cholesterol levels