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[98] Once, there was thought to be a positive feedback loop at work (a 'Vicious Cycle')

These cellular abnormalities collectively contribute to a maladaptive immune environment that accelerates CKD progression

This leukocytosis can result from many factors, including glucocorticoid-induced leukocytosis, anemic hypoxia, thromboembolic disease and tissue necrosis.27 Low platelet counts are reported up to 67% of the time.4 Concurrent immune-mediated destruction of RBCs and platelets (Evans syndrome) has been reported, but thrombocytopenia due to hypercoagulability and resulting consumption is more common

BMC Cancer 4:70