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The opioid receptors and their endogenous ligands are differentially expressed throughout the brain (Le Merrer et al., 2009

However, the cognitive enhancing effects of PregS in healthy subjects are unlikely to be due to the PREG metabolite ALLO since acute administration of this and other GABAergic modulating neurosteroids to healthy subjects inhibits learning and memory function in a manner similar to benzodiazepines (187191)