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Acknowledgments The authors thank the Department of Orthopedic Surgery for the academic and administrative support

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Phase 3 represents the early secretory phase and is marked by upregulation of MTF1 , a transcriptional activator of the metallothionein I promoter regulating the expression of multiple metallothionein I genes ( MT1E, MT1F, MT1G, MT1X ) [11, 22] (Fig

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