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[10] [12] These interactions are supported by pharmacokinetic studies, clinical observations, and drug interaction databases

The 2018 paper in Biochemical Pharmacology gave obese mice a membrane-permeable NNMT inhibitor and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with the mice eating the same amount as before, and the authors noting the inhibitors did not impact total food intake nor produce any observable adverse effects [1]

Abstract Cellular metabolism-related epigenetic modulation plays a pivotal role in the maintenance of cellular homeostasis

The most important step is to work with a qualified healthcare professional