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as excess energy accumulates, white adipose tissue (WAT) cells undergo abnormal, hypertrophic growth, leading to poor blood supply (hypoxia), macrophage infiltration, and systemic inflammation

Heart, liver, spleen, lung, and kidney were collected and analyzed by using fluorescence mode (551/567 nm of excitation/emission) of small animal live imaging system (#IVIS spectrum, PerkinElmer, MA, USA)

No FDA approval: IGF-1 LR3 has never received regulatory approval for human therapeutic use and is restricted to research applications [12]

[DOI] [PMC free article] [PubMed] [Google Scholar] [116].Wright GL, Maroulakou IG, Eldridge J, Liby TL, Sridharan V, Tsichlis PN, Muise-Helmericks RC, VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase, FASEB J