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The importance of these early signs is highlighted by S Boukssim from the Department of Oral Surgery, Faculty of Dentistry, Mohammed V University: "These oral changes may precede systemic symptoms of pernicious anaemia, underscoring their importance as early indicators of pernicious anaemia" [1]

DOI: [3] Gwyer D, Wragg NM, Wilson SL

Each 100-l cell suspension was then labelled for 20 min in the dark with the same volume of Annexin-V/7-amino-actinomycin D (7-AAD) reagent (Muse Annexin-V & Dead Cell kit, Merck Millipore)

A neurologist can perform nerve conduction studies, order appropriate blood work, and potentially perform a skin biopsy to establish an objective baseline against which to measure changes