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This inconsistency may stem from differences in sample collection periods (ranging from 3 to 30 days to 16 months), different populations (Thailand, Brazil, Switzerland, and Poland), and technical variations in the methods used (such as Creamatocrit and Human Milk Analyzer)

It has been reported that HDAC activity is involved in RA synovial are significantly increased compared with normal controls and are in direct proportion to TNF- mRNA levels (301)

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