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Deficiency in vitamin B6 is commonly linked to malnutrition, alcoholism, malabsorption syndromes, or as an adverse effect of certain medications, such as cyclosporine, hydralazine, cycloserine, penicillamine, isoniazid, levodopa, phenelzine and chemotherapy treatments ( Pyridoxine is crucial for the biochemistry of the nervous system, playing a significant role in amino acid biosynthesis and degradation (57, 58)

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The NIH notes that high-dose oral supplementation "may be another treatment option" for pernicious anemia, though injections remain standard first-line therapy and the available randomized controlled trials comparing the two approaches are considered limited in quality

How does vitamin B12 deficiency cause neuropathy