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He pointed out that in the VALVE Study trial, in which an ACE-inhibitor (ramipril) was added to the combination of furosemide and pimobendan, the median survival time was only 214 days, and in the QUEST Study (in which the Stage C dogs received either pimobendan or benazepril), the median survival time was only 267 days for pimobendan

In conclusion, while current diagnostic algorithms offer valuable frameworks for assessing HFpEF, further research is needed to standardize their use, improve diagnostic accuracy, and ultimately tailor management strategies for this heterogeneous patient population [19]

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The softwares counting tool was used to count the cells after first selecting the cells inside the regions of interest with a selection tool