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The AR promoter had reduced accessibility as early as 5 days of SPA, which persisted at 26 days (Figure 5G), consistent with prior reports indicating that ligand-bound AR exhibits negative autoregulation at the level of AR gene transcription (31)

The Impact of Hormones, Medication, and Environmental Factors on Tear Osmolarity Hormones (cortisol, aldosterone, thyroid hormones, etc.), medications (antihistamines, beta-blockers, diuretics, isotretinoin, anti-cholinergics, etc.), and environmental factors all affect tear osmolarity and regulate tear-dependent eye protection

The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity