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Epigenetic reprogramming involves multiple layers, including DNA methylation, histone modifications, and chromatin remodeling, which can regulate gene expression patterns, leading to functional transformations in T cells during their long-term adaptation to the TME (60)

Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression

Conversely, efficient metabolic transitions can benefit health and influence lifespan, as evidenced by reduced disease incidence and prolonged lifespan associated with fasting 2,3,4,5,6

Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, et al