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In metastatic colorectal cancer, mutations of K-Ras have an adverse effect on response to anti-EGFR antibody and cetuximab [134]

The research team of Frias et al designed a 32-week, randomized, double-blind, parallel-group, active control trial that included adults with a diagnosis of type 2 diabetes and a body mass index of 27 and HbA1C levels ranging from 7.5% to 10% despite a daily dose of metformin

Early comparisons of retatrutide vs tirzepatide suggest this triple action may deliver greater weight loss results, though direct head-to-head trials have not been completed