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When the VWFA is underactive, children may struggle with reading fluency

Mutat Res 555(12):133148 Labsch S, Liu L, Bauer N, Zhang Y, Aleksandrowicz E, Gladkich J et al (2014) Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells

Indeed, since 1941, more than 60 compounds, with different mechanisms of action, have been evaluated in clinical trials for ALS treatment (Petrov et al., 2017), but only four of them have been approved by FDA for clinical use: riluzole (Rilutek, Tiglutik, Exservan), edaravone (Radicava), tofersen (Qalsody), and AMX0035 (Relyvrio), which was removed from the market in april 2024 due to negative topline data (NCT03127514)

[2] The problem is that those results are almost entirely from animals