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Common limiting factors Poor microvascular supply: Tendons and ligaments may not receive enough oxygen and nutrients to sustain remodeling Chronic inflammatory signaling: Inflammation may remain dysregulated after the initial stimulus Disorganized collagen remodeling: Tissue repairs, but strength and alignment remain suboptimal Age-related regenerative decline: Older tissues respond less robustly to growth factor signaling Incomplete post-procedure support: Biology is stimulated but not supported long term PRP and prolotherapy light the match

It is well reported that the constant activation of the NMDA and AMPA receptors modifies the homeostasis of intracellular calcium, thus modifying its function as a second messenger and major modulator of calcium-dependent enzymes, such as calmodulin and nitric oxide synthases 1 and 2 (NOS-1 and NOS-2)

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This is why we often include supporting nutrients in our formulations