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In a medium-scale (some 2500 patients) epidemiological study, the impact of chronic low-grade peripheral inflammation in APOE4 allele carriers was tested on the onset of AD (Tao et al

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A 2020 review concluded that although curcumin reduced inflammatory cytokines and improved some clinical parameters, overall outcomes such as lesion erythema, pain, and ulcer size were not significantly different from placebo or corticosteroids (Lu et al., 2018)