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Its core pathogenesis lies in the synergistic interaction between genetic susceptibility (e.g., gene variants) and environmental triggers (e.g., ultraviolet radiation and gut microbiota dysbiosis), leading to multiple immune system disorders

One study investigated DNA methylation levels in males following one night of sleep deprivation (Cedernaes et al., CLOCK ), cryptochrome circadian clock 1 ( CRY1 ), brain and muscle ARNT-like 1 ( BMAL1 ) and period circadian clock 1 ( PER1 )

Chen H, Cheng J, Cai X et al (2022) pH-Switchable antimicrobial supramolecular hydrogels for synergistically eliminating biofilm and promoting wound healing

We will use the Bayley-III scores at 6 and 12 months in separate analyses where B 12 supplementation is the main exposure