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The TME is a complex and multi-layered structure, primarily consisting of cancer cells, cancer-associated fibroblasts (CAFs), cells that suppress the immune system (such as tumor-associated macrophages [TAMs], myeloid-derived suppressor cells [MDSCs], and regulatory T cells), cells that activate the immune system (including natural killer [NK] cells, dendritic cells [DCs], and T cells), and a variety of signaling molecules [3336]

At the metabolic level, AOD 9604 promotes triglyceride hydrolysis while concurrently reducing lipogenic activity through modulation of enzymes such as acetyl-CoA carboxylase

Methylcobalamin, on the other hand, is a naturally occurring form of B12

Voets, P