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doi: 10.1038/labinvest.2017.21 111 IsseFAEl-SherbeniAAEl-KadiAOS

It appears to be genuinely synergistic, with the combination producing more weight loss than you would expect from simply adding the individual effects together

ALAS exists in two isoforms: ALAS1 (ubiquitous) is feedback-inhibited transcriptionally by heme and induced by drugs metabolized by heme-containing cytochrome P450 enzymes