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While pre-fibrillar and fibrillar SOD1 aggregates exhibit significant toxicity, this effect is absent in curcumin-treated samples, suggesting its ability to neutralize harmful intermediates ( 4.4 Huntingtons disease 4.4.1 Pathogenesis of HD Huntingtons disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline and psychiatric disturbances, which typically manifests in mid-adulthood with an average age of 3050 years old (Wise, 2010

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Binding and modification of proteins by methylglyoxal under physiological conditions: a kinetic and mechanistic study with N-acetylarginine, N- acetylcysteine, and N-acetyllysine, and bovine serum albumin