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The synthesis of trimethylamine N-oxide (TMAO) and the development of cardiovascular risk exhibit another dimension to this dynamic activity, i.e., the interplay between the intestinal microbiome and the human host that occurs through the interaction of dietary intake (a type of environmental exposure) with the intestinal microbiota, leading to the production of metabolites that may serve as cardiac disease boosters (Tang et al., 2014a

Based on the population reference intake (PRI) values published by the Scientific Committee for Food (SCF, 1992 and 1993), the European Union set the recommended daily allowance (RDA) for iron to 14 mg/day (Annex to Directive 90/496/EEC amended by Commission Directive 2008/100/EC)

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