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This hypermethylation was associated with reduced mRNA and protein GR expression in the hippocampus, amygdala, striatum, and PFC (Brodmann Area 10), as well as altered expression of several other stress-responsive genes in the PFC (64)

Tremors, bradykinesia, and postural instability manifest following a 7080% depletion of dopaminergic neurons in the substantia nigra (SN) [3] and subsequently, dopamine release in the striatum is impaired [4]