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Footnotes Edited by: Yemin Wang, University of British Columbia, Canada Reviewed by: Afreen Saif, King George Medical University, India Le Anh Minh Nguyen, Western University, Canada Jianan Geng, Jilin Agriculture University, China Author contributions ZZ: Conceptualization, Visualization, Writing original draft, Writing review & editing

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Reviewer information Nature thanks Charles Mackay, Michel Nussenzweig and Hai Qi for their contribution to the peer review of this work