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the optimal dose was around 19 mg/day in early studies Subcutaneous injection (research community): 250500 mcg per day, typically once daily in the morning (fasted state preferred) Timing: Administration in a fasted state maximizes lipolytic response

Others who might be prescribed B12 shots are those at the highest risk for a B12 deficiency, including: Vegans, since vitamin B12 is found only in animal products People ages 60 and up since their bodies don't absorb B12 as efficiently People with Crohn's disease or pancreatic disease, since they prevent nutrient absorption People who had weight-loss surgery, which decreases B12 absorption People with an eating disorder People with HIV People with diabetes Since a mild B12 deficiency might not cause symptoms, it can go undetected for years since levels are not checked during routine blood work

From these results it was evident that B12 can be readily absorbed via the sublingual plexus and buccal cavity directly into the bloodstream

Proper dosing and monitoring are essential