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However, the LES competence can be difficult to assess preoperatively, because esophageal manometry can be unreliable in the presence of PEH [73]

Redox Biol 24:115

The statistically significant increase in the GSH:GSSG ratio in cases vs controls, despite this apparent artifact if it has happened, suggests that the changes in the glutathione redox status are robust and could be detected despite this experimental anomaly

This highlights why combining acetaminophen and alcohol, especially frequently or in high amounts, can accelerate liver injury and related diseases such as cirrhosis, which can be deadly