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In ASD, pathways such as the pentose phosphate pathway (PPP), pyruvate metabolism, mitochondrial fatty acid -oxidation, amino acid metabolism, heme synthesis, and porphyrin metabolism were downregulated, while O-glycan metabolism and fatty acid activation were upregulated (Figure S4)

159 However, two studies that compared the response of women with PCOS to that of healthy controls found that, while exercise did deliver many of the expected benefits to women with PCOS, it failed to alter the glucose-insulin dynamic in the body as a whole and in skeletal muscle, and it did not have the expected effect on fat burning