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These include synthetic pharmaceuticals such as metformin, phenformin or phenobarbital, as well as naturally occurring substances such as resveratrol, berberine [128], and, discussed in this article, CGA [129]

They participate in the metabolism of endogenous compounds, including hormones, fatty acids, and prostaglandins

Novel therapeutic strategies based on RCD mechanisms hold promise as effective approaches to control NAFLD/NASH and its progression to HCC

Specificity constant k cat / K M The k cat reflects nanozyme properties when active sites are saturated with substrate and loses its function at low substrate concentrations 90