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A 2021 study on nalfurafine, a -opioid agonist metabolized by cytochrome P450 into an inactive form, showed significant improvement in pruritus scores without notable adverse effects at doses of 2.5 mg and 5 mg, regardless of daytime or nighttime itching (24)

Antimuscarinics for Overactive Bladder Oxybutynin Trade Name: Ditropan Drug Class: Muscarinic antagonist Mechanism of Action: Muscarinic antagonist that is selective for M1 & M3 vs M2 receptors Relaxes the urinary bladder, and produces a antispasmodic effect

The activation of platelets and adherent leukocytes with platelets leads to the transmigration of leukocytes into inflammatory airway tissue with increased CysLTs, suggesting that platelet-aggregated granulocytes promote severe and persistent airway inflammation in NERD patients (Laidlaw and Boyce, 2013

furthermore, it significantly improves Cd resistance in yeast