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For instance, continuous increases in myelin debris cannot be accommodated by microglia in the long-term, which subsequently leads to dysfunctional lysosomal activity and a noticeable increase in insoluble lipofuscin-like granulesa marker of aging, dystrophy and possibly senescencein mice (Safaiyan et al., 2016)

However, the main difference between the main and minor branches were the diminishing in number of branches

Aquaporin-8 (AQP8) facilitates H 2 O 2 diffusion in GI (121)

As the main substrate of lipid peroxidation released from PL in the cell membrane, AA is a precursor of proinflammatory mediators that can be metabolized by cyclooxygenases (COX), ALOX, and CYP450 monooxygenases to synthesize biologically active inflammatory mediators, such as prostaglandins (PGs) and leukotrienes [91]