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Interestingly, the radial glial marker, slit guidance ligand 1, which is also usually considered to act as an inhibitory guidance cue during development, has been identified in the adult optic chiasm after an optic nerve crush injury, while other markers (radial glial cell marker 2, brain lipid binding protein) remain absent [430]

Iconography: Endothelin-1 levels in the pathophysiology of chronic obstructive pulmonary disease and bronchial asthma

Consistently, another study reported that patients hospitalized with COVID-19 who avoided ICU admission had higher serum RvE3 levels, reinforcing the association between PRLMs abundance and disease severity [203]

Notably, pharmacological modulation of autophagy/mitophagy through PI3K/Akt/mTOR pathway ameliorates both mitochondrial dysfunction and neuroinflammation while improving depressive-like behaviors [104], highlighting mitochondrial quality control as a key upstream regulator of inflammation