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Due to the generally higher metabolic activity in cancer cells and the increased levels of ROS associated with cancer progression, they may be more susceptible to ferroptosis ( 6 MM and ferroptosis 6.1 Lipid metabolism pathway 6.1.1 AA pathway Studies have demonstrated significant reductions in key PUFAs, including ferroptosis-inducing AA, within bone marrow aspirates of MM patients ( Intriguingly, MM plasma cells exhibit elevated GPX4 and xCT levels compared to normal counterparts

An elemental diet has also been shown to decrease inflammatory parameters in IBD intestinal tissue

from human THP-1 monocytic cells