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Ma H, Dong Y, Chu Y, Guo Y, Li L

Targeting Signal Transduction Pathways Which Regulate Necrosis in Acetaminophen Hepatotoxicity

62 Thus, consistent with the very low levels of LPO, 55,62 lysosomal ferrous iron translocated into mitochondria promotes MPTP opening and APAP-induced cell death through facilitation of protein nitration, rather than generation of LPO under normal conditions