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There are four tocopherol and tocotrienol isomers (, , , and )

SCIRI Spinal cord ischemia/reperfusion injury ROS Reactive oxygen BSCB Blood-spinal cord barrier O 2 - Superoxide anion H 2 O 2 Hydrogen peroxide OH hydroxyl radical I/R Ischemia reperfusion ETC Electron transport chain SOD superoxide dismutase XDH xanthine dehydrogenase XO Xanthine oxidase NADPH Phosphamide adenine dinucleotide PRDX2 Peroxidase 2 mPTP Endometrial permeability transition pore m membrane potential Cyt C Cytochrome C GSDMD gasdermin-D Apaf-1 Apoptotic protease activator-1 mtROS Mitochondrial reactive oxygen species HIF-1 Hypoxia-inducible factor-1 GSH Glutathione GPX4 Glutathione peroxidase 4 Nrf-2 Nuclear factor erythrocyte 2-related factor 2 ARE Antioxidant response element Keap1 Kelch-like epichlorohydrin-associated protein-1 HO-1 Heme oxygenase-1 NQO1 Quinone oxidoreductase-1 GPX glutathion peroxidase NF-B Nuclear factor-B MDA Malonaldehyde RIPC Remote ischemic preconditioning MAPK mitogen activated protein kinase MMPs Matrix metalloproteinase ERK Extracellular signal-regulated kinase JNK c-Jun NH 2-terminal kinase Sal salidroside BA Biochanin AST astaxanthin GRb1 Ginsenoside Rb1 MAP3K APK kinase kinases Glossary References 1 Abdel-WahabB

Pinealon belongs to a class of drugs called peptide bioregulators, or biochemical compounds that come from naturally occurring organisms