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More recently, it has been shown that, still via the ANS, a peripheral inflammation can induce the appearance in the insular cortex, of inflammation-specific engrams associated with specific ensemble of neurons

doi: 10.3945/jn.117.255901 34

doi: 10.1038/s41419-024-06558-0

These inflammatory proximal tubular cells can significantly downregulate GSH metabolic genes, making cells more prone to ferroptosis, resulting in repair failure after kidney injury, ultimately promoting kidney fibrosis and the progression of AKI to CKD (209)