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Methionine is converted to S-adenosylmethionine (SAM) by methionine adenosyltransferase (MAT), which then creates S-adenosylhomocysteine (SAH) via TSS.SAH is converted to homocysteine (HCY), a precursor of cysteine, by S-adenosylhomocysteine hydrolase (SAHH) (99, 100)

Overall, this simultaneous loss of energy production and insufficient mGSH results in decreased resilience against amyloid-beta and tau, further fueling neuronal loss and leading to increased cell death and an increased rate of neural decline

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(2) Propagation, where the lipid radicals react with oxygen, leading to production of lipid peroxyl radicals (LOO ), which further react with additional PUFA-containing phospholipids, producing lipid peroxides ((LOOH)) and propagating the lipid peroxidation chain reaction