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In addition to its role in purine catabolism, XOR exhibits nitrite reductase activity to produce nitric oxide and NADH oxidase activity to generate ROS under hypoxic, acidic, and inflammatory conditions [14]

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To determine the robustness of the screen the statistical parameter, Z-prime (Z) was determined (25) and at 40 hours of growth the values obtained were very significant (for Screen I =0.95 and for Screen II = 0.91) which suggested that the screens we developed were robust and would be compliant for a high throughput setting (Figure S6)

The best theory is that Prozac interferes with enzymes that metabolize cocaine