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These include metformin use for type 2 diabetes the MHRA advised in 2022 that people on long-term metformin should have their B12 levels monitored long-term proton pump inhibitor (PPI) medications for reflux, vegetarian or vegan diets, and conditions affecting absorption such as pernicious anaemia or coeliac disease

The existing studies which have focused primarily on the relationship between micronutrients and sleep duration have yielded inconsistent results regarding the impact of vitamin B12 on sleep patterns [21]

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